【代表性科研项目】

1.国家重点研发计划项目（2022YFC2104900），绿色工业酶催化合成营养化学品关键技术，主持。

2.国家重点研发计划课题（2019YFC1604602），食品中农兽药残留物降解技术及安全性评价，主持。

3.国家自然科学基金优秀青年基金（31922073），食品酶与食品酶工程，主持。

4.国家自然科学基金面上项目（22278183），β-（2, 6）果聚糖蔗糖酶的糖链延伸机制解析及链长调控，主持。

5.国家自然科学基金面上项目（21276001），基于定向进化技术的L-阿拉伯糖异构酶分子改造研究，主持。

6.国家自然科学基金面上项目（31171705），己酮糖3-差向异构酶的构效关系与分子改造，主持。

【英文专著】

1.Mu W, Zhang W, Chen Q. Novel enzymes for functional carbohydrates production: From scientific research to application in health food industry [M].Springer Nature, 2021. (ISBN 978-981-336-021-1)

【代表性论文】

1. Zhu Y, Zhang J, Zhang W,Mu W. Recent progress on health effects and biosynthesis of two key sialylated human milk oligosaccharides, 3’-sialyllactose and 6’-sialyllactose.Biotechnol Adv, 2023, 62: 108058. IF 17.681

2. Meng J, Zhu Y, Chen R, Liu Y, Zhang W,Mu W.Microbial synthesis of L-fucose with high productivity by a metabolically engineeredEscherichia coli.J Agric Food Chem, 2023, 71(5): 2464-2471.IF 5.895

3. Chen R, Wan L, Zhu Y, Liu Y, Zhang W,Mu W. Spatial organization of pathway enzymes via self-assembly to improve 2'-fucosyllactose biosynthesis in engineeredEscherichia coli.Biotechnol Bioeng, 2023, 120:524-535. IF 4.395

4.Ni D, Chen Z, Tian Y, Xu W, Zhang W, Kim BG,Mu W. Comprehensive utilization of sucrose resources via chemical and biotechnological processes: A review.Biotechnol Adv, 2022, 60: 107990. IF 17.681

5.Chen Q, Wu Y, Huang Z, Zhang W, Chen J,Mu W. Cold-active enzymes in the dairy industry: Insight into cold adaption mechanisms and their applications.Trends Food Sci Technol, 2022, 125: 126-135. IF 16.002

6.Fang Y, Huang Z, Xu W, Wang C, Sun Y, Zhang W, Guang C,Mu W. Efficient elimination of zearalenone at high processing temperatures by a robust mutant ofGliocladium roseumzearalenone lactonase.Food Control, 2022, 142: 109222.IF 6.652

7.Tian Y, Hou X, Ni D, Xu Wei, Guang C, Zhang W, Chen Q, Rao Y,Mu W. Structure-based interface engineering methodology in designing a thermostable amylose-forming transglucosylase.J Biol Chem, 2022, 298: 102074.IF5.485

8. Ouyang B, Xu W, Zhang W, Guang C,Mu W. Efficient removal of sulfonamides and tetracyclines residues by the laccase-mediator system employing a novel laccase fromLysinibacillus fusiformis.J Environ Chem Eng, 2022, 10: 108899.IF7.968

9.Zhu Y, Cao H,Wang H,Mu W. Biosynthesis of human milk oligosaccharides via metabolic engineering approaches: Current advances and challenges.Curr Opin Biotechnol, 2022, 78: 102841.IF 10.279

10. Wu H,Mu W.Application prospects and opportunities of inorganic nanomaterials for enzyme immobilization in the food-processing industry. Curr Opin Food Sci, 2022, 47: 100909. IF 9.8

11.Xu W, Ni D, Hou X, Pijning T, Guskov A, Rao Y,Mu W. Crystal structure of levansucrase from the gram-negative bacteriumBrenneriaprovides insights into its product size specificity.J Agric Food Chem, 2022, 70(16): 5095-5105.IF 5.895

12. Zhao S,Xu W, Zhang W, Wu H, Guang C,Mu W.In-depth biochemical identification of a novel methyl parathion hydrolase fromAzohydromonas australicaand its high effectiveness in the degradation of various organophosphorus pesticides.Bioresource Technol, 2021, 323: 124641.IF 11.889

13. Wang Y, Wu H, Zhang W, Xu W,Mu W. Efficient control of acrylamide in French fries by an extraordinarily active and thermo-stable L-asparaginase: A lab-scale study.Food Chem, 2021, 360, 130046.IF 9.231

14.Xu W,Zhao S,Zhang W, Wu H, Guang C,Mu W.Recent advances and future prospective of organophosphorus-degrading enzymes: identification, modification, and application.Crit Rev Biotechnol, 2021, 41(7): 1096-1113. IF 9.062

15.Hu D, Wu H, Zhu Y, Zhang W,Mu W.EngineeringEscherichia colifor highly efficient production of lacto-N-triose II fromN-acetylglucosamine, the monomer of chitin.Biotechnol Biofuels, 2021, 69(44): 13125-13134.IF 7.67

16.Wan L, Zhu Y, Chen G, Luo G, Zhang W,Mu W. Efficient production of 2’-fucosyllactose from L-fucose via self-assembling multienzyme complexes in engineeredEscherichia coli.ACS Synth Biol, 2021, 10: 2488-2498. IF 5.249

17. Chen Q, Xiao Y, Zhang W,Mu W.Current methods and applications in computational protein design for food industry.Crit Rev Food Sci Nutr, 2020, 60(19): 3259-3270.IF 11.208

18. Zhang Z, Chen M, Xu W, Zhang W, Zhang T, Guang C,Mu W.Microbial phospholipase D: Identification, modification and application,Trends Food Sci Technol, 2020, 96: 145-156. IF 16.002

19. Xu W, Peng J, Ni D,Zhang W, Wu H,Mu W.Preparation, characterization and application of levan/montmorillonite biocomposite and levan/BSA nanoparticle.Carbohyd Polym,2020, 234(15): 115921.IF 10.723

20.Ni D, Chen Z, Xu W, Zhang W,Mu W.Efficient production of inulin and oligosaccharides using thermostable inulosucrase fromLactobacillusjensenii.Int J Biol Macromol, 2020, 165: 1250-1257.IF 8.025

【代表性科研获奖】

1.低聚半乳糖、低聚果糖、低聚异麦芽糖生物加工关键技术及产业化，山东省科技进步一等奖

2.糖质资源高值化绿色利用关键技术及应用，科技部科学技术进步二等奖

3.乳糖资源高效生物加工关键技术，中国石油和化学工业联合会科技进步二等奖

4.菊糖资源高效生物加工关键技术，中国石油和化学工业联合会科技进步二等奖

5.功能性氨基酸酶法合成关键技术，商业联合会科技进步一等奖

6.糖质资源高效生物利用及功能性糖生物制备关键技术，商业联合会科技进步二等奖

代表性专利：

1.沐万孟；江波；郁书怀；朱莺莺；张涛，Highly efficient method for synthesizing difructose anhydride III, US2019/0002939A1

2.沐万孟；张文立；黄嘉苇；江波；张涛，一种热稳定性提高的D-阿洛酮糖3-差向异构酶突变体，ZL201810059404.6

3.沐万孟；张文立；黄嘉苇；江波；张涛，一种催化效率提高的D-阿洛酮糖3-差向异构酶突变体，ZL201810060068.7

4.沐万孟；张文立；倪大伟；徐炜，一种产蔗果三糖的菊糖蔗糖酶突变体，ZL202110613892.2

5.沐万孟；张文立；万李；朱莺莺，一种高效生产2′-岩藻糖基乳糖的大肠杆菌工程菌株，ZL202110389910.3

6.沐万孟；张文立；李雯；朱莺莺；万李，一种高效生产2′-岩藻糖基乳糖的重组菌的构建方法及应用，ZL 201911188891.7

7.沐万孟；张文立；万李；朱莺莺；李雯，一种高效生产GDP-岩藻糖的大肠杆菌工程菌株，ZL201911092950.0

8.沐万孟；张文立；朱莺莺；万李，一种提高乳酰-N-三糖II产量的基因工程菌及生产方法，ZL2020108346573

9.沐万孟；张文立；徐炜；张振霞，一种真菌毒素ZEN降解酶突变体及其应用，ZL201911024030.5

10.沐万孟；张文立；张振霞；徐炜，一种热稳定性提高的玉米赤霉烯酮降解酶突变体及其应用，ZL201911023315.7

本科生课程：

1. 生物技术

2. 食品化学实验

3. 基因工程综合实验

研究生课程：

1. 酶工程原理与酶应用技术

累计培养硕士研究生46人，博士研究生19人。指导学生荣获江苏省优秀硕士专业论文2人次、江苏省优秀本科生论文2人次、太阳集团见好就收9728优秀博生毕业论文2人次、太阳集团见好就收9728优秀硕士毕业论文4人次；国家奖学金31人次、金龙鱼和康师傅等社会奖学金26人次；无锡市三好学生、校优秀毕业研究生、校优秀研究生干部14人次；主持江苏省硕士研究生/博士研究生创新计划项目、太阳集团见好就收9728优博培育基金15人次。13名学生赴美国哈佛大学、罗格斯大学、伊利诺伊斯理工大学、日本大阪大学、荷兰格罗宁根大学、加拿大英属哥伦比亚大学、韩国首尔国立大学、芬兰图尔库大学、澳门大学等国际著名高校联合培养或攻读学位；部分毕业生进入宝洁、惠氏、可口可乐等知名企业工作。

每一位研究生都有无穷的潜力，欢迎有志于食品生物技术研究的同学报考！这里将给予大家最好的平台，共同创造美好未来！